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“Everybody dr. O in this video i want to talk about id 50 and nld nld 50. So id. 50.
Is the infectious. Dose. 50. Which is the dose.
The of organisms nthat. It would take to cause an infection in 50 of people so it s a good measure of how virulent a nmicrobe is how easy how easily it can cause infection. The ld 50. Now just so you know i generally nonly think of toxins.
When i think of the ld 50. So it s the lethal dose 50. But technically nit would be you know how many viruses. How many bacteria or how many toxins would it ntake to kill 50 of infected people so but for me i think infectious dose.
I nthink of how easily something can cause an infection lethal dose. I m generally thinking nof toxin. So to me it s the best way to measure how potent a toxin is so here we see just a picture that kind of nshows. The general idea this isn t any specific organism.
But you see how many organisms it ntakes to cause mortality in 50 of people so that s how you figure these out so. I think it s super important as we move non here to a list to understand that these are medium values. Which means that if you nhave a very strong immune system. You re very healthy.
A lot of stomach acid. Whatever nfactor might come into play. It would take a much higher number for you. But someone nthat s malnourished and has other problems.
The number would be a lot lower. So this is not an exact number by any means nit s a great way to compare one organism to another the other thing. That s worth noting. Here nlet.
Me show you an example would be oh. I two mouse arrow. There. So you have like let s see salmonella nenterica serovar typhi.
There it takes about a thousand organisms to uh to cause an infection nbut. The mortality rate of this typhoid fever that can be caused by this is about 10 whereas. Nright below. It the salmonella enterica serovar typhimurium.
This is going to lead to just nyour more. Quote unquote basic salmonellosis which. Has a mortality rate of around 1 especially npeople that are getting treatment. So you notice that the infection dose.
Really nhas nothing to do with how dangerous an organism would be alright. So just a couple of examples there nand. I apologize for that arrow. There must have been there when i took the screenshot nof this you ll see the viruses are generally going nto be pretty low.
But look at like the difference between the different types of e coli. So nyour e coli 0157 h7. You know one of the most potentially dangerous forms of e coli. Nthe infectious dose is pretty low this says.
Ten to one hundred. I ve seen some studies nthat put that infectious dose between like four and five organisms so very very. Small nnumbers. Whereas.
Look at some of these other strains like enterotoxigenic strains of e. Ncoli takes between what is that ten million and ten billion organisms to actually cause nan infection. So the infectious dose basically tells you nhow many organisms do you have to be exposed to before you have a problem see like cholera down. There at the bottom nthat s going to be about a million.
So a much higher number than some of these other nones. Okay uhm one more thing to think about here. Nwith infectious. Does is the way in the portal of entry.
So here s an example of an organism nbacillus anthracis. Which causes anthrax that has a different infectious dose. Depending non the portal of entry. So it takes ten to fifty endospores to cause ncutaneous anthrax with skin when they come into contact with your skin inhalation anthrax.
Which is generally what nwe think of especially with being used as a biological weapon. Ten to twenty thousand nendospores and then ingestion anthrax would be two hundred nand. Fifty thousand to a million endospores. So the portal of entry matters.
Just a couple more numbers here with the lethal ndose just as a comparison so again it tells you how toxic a toxin nis right how potent a toxin is or needs to be to actually lead to death or serious nillness. So you see here that like botulinum toxin nonly take 03 nanograms per kilogram. Whereas. The shiga toxin.
Which is what e coli 0157. H7. Nthe. Enterohemorrhagic.
E. Coli s would release two hundred and fifty nanograms per. Kilogram nand. Then staphylococcal enterotoxin takes one thousand three hundred and fifty nanograms nper kilogram.
So you re looking at a massive difference nin how much of a toxin. It takes to be lethal alright. So that is the id. 50.
The infectious ndose 50. And the ld 50. The lethal dose 50. I hope this helps have a wonderful day.
just kind of the unbox unboxing set up and don t worry i will figure out those cables down there but uh yeah. That s about it for this video. ” ..
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