Concealed Allocation: What Is It and Why Is It Important?

what is allocation by need This is a topic that many people are looking for. bluevelvetrestaurant.com is a channel providing useful information about learning, life, digital marketing and online courses …. it will help you have an overview and solid multi-faceted knowledge . Today, bluevelvetrestaurant.com would like to introduce to you Concealed Allocation: What Is It and Why Is It Important?. Following along are instructions in the video below:

“There dr. Terry shanty. Fell for uab school of medicine concealed allocation is often confused confused by readers of randomized control trials with blinding in this video. I ll discuss concealed allocation is and how it s carried out and will also discuss how concealed allocation is critical to maintaining the integrity of the randomization process.

So let s say you want to do a study to figure out if a blue pill is better than a red pill at preventing death and the best way to do a therapeutic studies to do a randomized control trial. So you would randomize patients to a blue pill and red pill. And you d have an equal distribution of prognostic factors between those on the blue pill and the red pill. But what if you are a clinician or researcher.

And you had your next patient who potentially could be in this study. And you re really concerned about them they were very sick. And you wanted to make sure they got the blue pill and let s really consider that you could figure out the randomization scheme. You could know what s coming next.

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Whether. A blue pill would be assigned next or red pill. And you hold this patient out. So that they get the blue pill.

Now what problem could there be with that well that s where allocation concealment comes in now randomization is great at equally distributing prognostic factors. But it can be overcome or the benefits of randomization will be overcome if proper allocation concealment is not done so what is allocation concealment. What s not disclosing to patients or to those enrolling people in the trial. The allocation or randomization sequence and this differs from blinding when we think about double blinding in a study because blinding occurs after randomization.

It s not letting the researchers or the patients know what treatment. They re on after randomization. So you can think of allocation concealment. As pre randomization blinding.

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You re blinding. The randomization scheme and traditional blinding is post randomization blinding. Now why is allocation concealment. Important well it s important because if you have inadequate allocation concealment.

You can overestimate treatment effects by up to 40 you can make your treatment. Look better than it really is now the other thing. It does is help to avoid selection bias and selection bias. Here s a little bit different than we think of in a case control study.

But selection buys here are systematic differences between patients who recruited to a trial and those who are not recruited so that the trial population is not representative of the patient population and that may be the case because you can figure out randomization your whole patients out and you only put certain patients in the study into certain treatments. It also helps avoid allocation bias and allocation biases systematic differences between participants in how they were randomized to treatment and here it s because you can figure out the the randomization scheme. So you put patients that have different prognosis into one arm of the study or another. Because you want them to get a certain treatment.

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So how do you know if there is adequate allocation. Consuming well certain things you can look for one of them is sequentially numbered. Opaque. Sealed envelopes so the envelopes all have a number on it when the next patient comes up you grab the next numbered envelope.

It s opaque. So that you can t see through it and figure out what the randomization scheme is and it s sealed. So that you can t open it prior to enrolling the patient often pharmacies will control randomization. So once you enroll a patient you call into the pharmacy and they disclose the randomization of that individual patient probably.

The most commonly done thing is calling into a central randomization center of the study center and the central center will tell you which arm of the trial. Your patient is randomized to importantly just use your clinical judgment. Does it look like the randomization scheme could be broken. If not then you can be assured that adequate concealed randomization was probably done.

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So. Let s test your knowledge. And see. If you understand concealed allocation pause.

The video for a minute select. These answers that you think are true and then restart the video to see your answer so let s see how you did so these two answers are correct. ” ..

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